Major Differences between Nuvigil and Provigil (Nuvigil Vs Provigil)

Nuvigil vs Provigil

Many people are confused as if Modafinil and Provigil are two different medicines (when it comes to narcolepsy treatment) even though they are two different medicines of the same formula only the names are different, but it should be known that Armodafinil can be called Nuvigil or Modafinil can also be called as Provigil. When it comes to compare Nuvigil and Provigil (Nuvigil vs Provigil) there are a few difference between the two and we have tried to clarify them in this blog.

What is Nuvigil (Armodafinil)?

Eugeroic modafinil has an enantiopure molecule called armodafinil (Nuvigil). Only the racemic modafinil enantiomer is present in it. The U.S. Food and Drug Administration gave armodafinil (Nuvigil) its seal of approval in June 2007 and Cephalon Inc. is the manufacturer.

What is Provigil (Modafinil)?

Narcolepsy, shift work sleep disorder, and obstructive sleep apnea is three conditions that can cause excessive daytime drowsiness. Modafinil (Provigil), a central nervous system stimulant drug, is one such example and is marketed under the trade name Provigil.


Nuvigil vs Provigil:

Active IngredientArmodafinilModafinil
FDA Approved UsesNarcolepsy, Obstructive sleep apnea, Shift work sleep disorder, ADHDNarcolepsy, Obstructive sleep apnea, Shift work sleep disorder, ADHD
Dosage Forms AvailableTabletTablet
Duration of Effect12-15 hours8-10 hours star start start
Start to the Actionwithin 1 hourwithin 2-4 hours
Common Side EffectsNausea, Vomiting, Insomnia, Lightheadedness, Diarrhea, etc.Nausea, Vomiting, Insomnia, Lightheadedness, Diarrhea, etc.
Chance/ Risk of Dependence & AbuseLowLow

Please be aware that while this table intends to provide an overview, individual results may diverge. A healthcare professional should be consulted for specific medical advice.

Does Nuvigil have more potency than Provigil?

Is modafinil (Provigil) superior to armodafinil (Nuvigil)? The efficacy and safety of modafinil (Provigil) and armodafinil (Nuvigil) are comparable. Over the day, armodafinil (Nuvigil) levels may rise in the body, though. In comparison to modafinil (Provigil), armodafinil’s (Nuvigil) effects could last longer.

What class does Provigil belong to?

Medications in the stimulant family include Provigil. It is offered in oral tablet dosages of 100 mg and 200 mg. According to studies, those who suffer from narcolepsy, sleep apnea, or shift work sleep disorder might stay up longer while using Provigil compared to a placebo.

What class does Nuvigil belong to?

Modafinil’s sole isomer, Nuvigil (armodafinil), is a stimulant. It is unclear what exactly causes the effect. Eugeroics are a class of medications that are stimulants that offer sustained mental stimulation, and armodafinil is one of these drugs.

Does Nuvigil help you Focus?

Your ability to concentrate, think, and act differently can be affected by armodafinil (Nuvigil). Even though the drug can increase alertness, some extremely sleepy people may still find it difficult to stay awake while using armodafinil (Nuvigil).

Does Provigil help you focus?

According to the research, the Researchers concluded that modafinil (Provigil)is more likely to aid boost attention and learning for more complicated thinking processes than for simple activities after reviewing 24 studies that looked into the usage of the drug in healthy, non-sleep-deprived adults.

Dosage Of Nuvigil For Obstructive Sleep Apnea And Narcolepsy (OSA):

For people with OSA or narcolepsy, NUVIGIL should be taken orally once daily in a single dose in the morning at a dose of 150 mg – 250 mg.

While doses up to 250 mg/day have been tolerated well [see CLINICAL PHARMACOLOGY and Clinical Studies], there is no compelling proof that dosages higher than 150 mg/day, given as a single dose, provide any significant advantages beyond those provided by the 150 mg/day dose in OSA patients.

A single oral dose of 150 mg of NUVIGIL should be administered daily to SWD patients, ideally an hour before the start of their shift.

Sticking to your doctor’s dosage recommendations and not over the highest dose permitted is pivotal.

Dosage of Provigil for Narcolepsy and Obstructed Sleep Apnea:

It is recommended that people with OSA or narcolepsy take a single dose of 200 mg of PROVIGIL /per day.

Although single doses up to 400 mg/day have been well tolerated [see CLINICAL PHARMACOLOGY and Clinical Studies], there is no trustworthy evidence that this dosage provides any additional benefits over 200 mg/day of dosage.

For people with SWD, a single oral dose of PROVIGIL 200 mg should be given once daily, about an hour before the patient’s shift.

Following your doctor’s dosage advice and not exceeding the maximum dosage allowed are crucial.

Benefits of Nuvigil:

When a person has narcolepsy, obstructive sleep apnea, or a shift work issue, they may use the drug Armodafinil (Nuvigil) to help them.

Among the possible advantages of Nuvigil, are:

  • Escalating restraint and wakefulness
  • Enhancing cognitive function
  • Reducing unnecessarily long days of sleep
  • Boosting the general quality of life for individuals suffering from sleep disorders

Benefits of Provigil

Various studies have demonstrated that when compared to a placebo, Provigil (modafinil) tends to increase the capacity of an individual with narcolepsy, sleep apnea, or a shift work sleep disorder to simply stay awake. Provigil is frequently the first medication to treat these disorders and lowering fatigue.

Precautions to take with Nuvigil (Armodafinil)

You shouldn’t take Nuvigil if you have ever had an allergic reaction or rash brought on Nuvigil. Immediately stop taking Nuvigil and call your physician if you notice any skin sensitivity, no matter how slight.

Provigil (Modafinil) Precautions to take:

There is a slight chance that this medication will trigger skin reactions. If while taking this medication you experience blistering, peeling, or loosening of the skin, red skin lesions, rasher, stop taking it immediately and see your doctor.

Major similarities between Provigil and Nuvigil?

Provigil and Nuvigil may help adults who have a documented tendency to drowsiness during the day feel more alert and awake. These medications are not meant to treat sleep disorders or serve as a substitute for getting enough sleep. In headache, their respective mechanisms of action, the drugs Provigil and Nuvigil are majorly similar since both of them work as cognitive enhancers, according to Provigil and Nuvigil reviews

Side-effects of Nuvigil:

The following worsens might appear headache, nausea, dry mouth, anxiety, vertigo, or trouble sleeping. Inform your doctor or pharmacist immediately if any of these symptoms persist or worsen. You should keep in mind that your doctor recommended this drug because she or he thought it would benefit you more than it would harm you.

Side-effects of Provigil:

  • Headache
  • Nausea.
  • A sensation of unease.
  • Anxiety.
  • Difficulty sleeping
  • Decrease in appetite
  • Dizziness

Is Nuvigil Better than Provigil?

The brand names of the generic medication armodafinil and modafinil are Nuvigil and Provigil, respectively. Narcolepsy, sleep apnea, and shift work sleep disorder are all conditions that are treated with both medications. Nuvigil, on the other hand, is the R-enantiomer of modafinil, whereas Provigil is a racemic mixture of the R- and S-enantiomers. More research is required to confirm however,  some studies that claim the R-enantiomer may be more useful for treating conditions like narcolepsy. The side effects and precautions for both medications are similar.

References for Nuvigil vs Provigil:
















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About the author
Greg Nicholl
Greg Nicholl, CEO
Greg has over 20 years of experience in the pharmaceutical industry. They hold a Masters Degree in Urology. Greg uses their expertise to create informative and engaging content for
Greg can be reached via email at [email protected].

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